TRF Platform

Precision Biosensor is the only company in the world
providing image-based TRF POCT products which have a high sensitivity and
accuracy that can detect single-digit picograms(pg) of biomarkers at a relatively reasonable price.
Time-Resolved Fluorescence Imaging Technology
Exdia TRF Analyzers use large stokes shift and long decay time of Europium and eliminate background from the detection signal,
leading to an enhanced sensitivity compared to the existing fluorescence POCT products.
TRF Measurement
Signal Comparison of Fluorescence vs TRF
Platform Label Cost Sensitivity/specificity Complexity
Absorbance / Reflectance Gold
Latex
Carbon
Low Low / Low Low
Conventional Fluorescence Fluorescent dye High High / Low High
Time-Resolved Fluorescence Eu particle Moderate High / High Moderate
Exploration of TRF sensitivity using Exdia TnI
- Discrimination of 3.3 pg/mL from 2.0 pg/mL (in comparison with Architect Tnl, Abbott)
TRF Core Technology
Based on image processing technology accumulated through experience in the development of camera sensors for satellites,
Precision Biosensor can quantitively detect and analyze immunodiagnosis cartridges with TRF technology by
combining 2D image-based microlight detection technique and GHz optical timing control technique.
CARTRIDGE
Core Technology
  • Antibody Development & Production
  • Proteomics
  • LFA Multi-plexing Assay
  • LFA reagent formulation
  • LFA Fluid-controlling Technology
  • LFA Cartridge Mass-production Technology
  • LFA Dynamic Range Extension Technology
ANALYZER
Core Technology
  • Simultaneous Acquisition of Image Data
  • Accurate Control of Measuring Time
  • AI-based Image Processing
  • Image Processing Simulator
  • Light Intensity Control
  • Light Reflectance Correction
  • Large-capacity Image Data Processing
CARTRIDGE
Core Technology
  • Antibody Development & Production
  • Proteomics
  • LFA Multi-plexing Assay
  • LFA reagent formulation
  • LFA Fluid-controlling Technology
  • LFA Cartridge Mass-production Technology
  • LFA Dynamic Range Extension Technology
ANALYZER
Core Technology
  • Simultaneous Acquisition of Image Data
  • Accurate Control of Measuring Time
  • AI-based Image Processing
  • Image Processing Simulator
  • Light Intensity Control
  • Light Reflectance Correction
  • Large-capacity Image Data Processing
TRF-related Intellectual Property Rights
Classification Title Registration No.
Patent Time Resolved Fluorescence Module and Immunoassay Method Using the Same 10-1218178
Patent Image Obtaining Device and Method of Obtaining Image 10-1336228
Patent Diagnostic Apparatus 10-1661986
Software Exdia TRF Plus C-2019-020059
Software Exdia TRF C-2019-020061
Software Fluoro-Checker™ TRF C-2019-020062
TRF-related National Projects
Authority Title Period
Ministry of Knowledge Economy Highly Sensitive Detection System with Europium Indicator 2009.12 ~ 2012.09
Small and Medium Business Administration Development of Imaging Spectrograph Device for Bio Diagnosis 2014.03 ~ 2016.03
Ministry of Trade, Industry and Energy Development of Diagnosis Technique for Acute Myocardial Infarction
Using Time-Resolved Fluorescence Technology
2017.08 ~ 2019.12
Small and Medium Business Administration Development of Non-sequential Multi-loading Type High-sensitivity Immunodiagnosis Analysis Device 2017.11~ 2019.10
Ministry of Science and ICT Development of High-sensitivity Screening Technology for Point-of-care Testing 2019.08 ~ 2022.07 (In Progress)
Ministry of Health and Welfare Development of High-sensitive Tuberculosis Diagnosis Technology for Point-of-care Testing
Using Novel Nano-composites and Immuno-fluorescence High-efficiency Signal Amplification
2020.04 ~ 2024.12 (In Progress)
RIGHT Fund Development of Mobile Diagnosis Platform for Simultaneous Detection of
Influenza A & B, SARS-CoV, and SARS-CoV-2 Infection
2020.07 ~ 2021.06 (In Progress)
Ministry of SMEs and Startups Development of Time-Resolved Fluorescence Imaging Analysis Technology for Point-of-care Testing
Using High-sensitivity Active Pixel Sensor
2020.11 ~ 2022.10 (In Progress)
TRF Targeting Areas
Precision Biosensor has been focusing our R&D on the biomarkers and areas that need higher sensitivity
which are difficult for the existing POCTs to access.